Morphologically Directed Raman Spectroscopy (MDRS)
- Determining particle morphology and composition of a component in a mixture, such as API particle size in a pharmaceutical formulation, generic drug development or cement research. The ability to exclude particles based on their composition allows for population isolation of particle size data through speciation.
- Identifying contaminants or outlier particles in a failing batch of material. Determining the composition of the contaminants can then allow determination of the origin source.
- Investigating unknown particulate samples such as the mineral composition of geological samples.
When an analysis is performed on the sample material, particles are measured for size and shape, and then particle classes are created. A morphological description of each identified particle can then be generated in the form of size and shape distributions using the data from the image analysis measurement. If a specific component is of interest, particles with a distinct morphology such as size range or shape parameters can be targeted for chemical analysis using Raman spectroscopy. The location of individual particles on the sample slide is recorded during the image analysis measurement. The instrument can then return to collect the Raman spectra of individual particles for identification against a spectral library.
MDRS is particularly well-suited to a wide range of organic and inorganic materials. Some sample materials are unsuitable for this type of analysis including metals, very dark or black samples, and samples which fluoresce at the wavelength of the laser light used (785 nm).
This technology is offered utilizing one of our newest instruments, the Malvern Morphologi 4-ID that couples Raman spectroscopy speciation with image analysis. This combination of analytical techniques allows comprehensive results and solutions to complex characterization problems.