In partnership with Spectradyne LLC, Particle Technology Labs has added a new nanoparticle analyzer, Spectradyne’s nCS1, to our particle size and characterization testing services.
Particles are measured using Microfluidic Resistive Pulse Sensing (MRPS), an extension of the well-known Coulter Principle. This method, which is electrical in nature, does not rely on an optical index contrast to distinguish particles from their suspending medium; it is therefore truly orthogonal to light scattering-based techniques. MRPS measures every particle individually, has a higher sensitivity for size and concentration, and can measure a wide concentration range. The technique uses a very small sample volume, approximately 3 μL. This makes it ideal for expensive or limited sample quantities or for an orthogonal measurement of samples already being analyzed at PTL.
From the manufacturer: “Spectradyne’s nCS1 measures individual nanoparticles while accumulating statistically-reliable distributions of particle sizes with quantitative concentration information. This unique capability separates the nCS1 from other technologies such as Nanoparticle Tracking Analysis (NTA) or Dynamic Light Scattering (DLS).”
Nanoparticles are used in cosmetics, food, pharmaceuticals and more, and as the nCS1 is able to accurately measure particles of any type, the instrument has a wide variety of applications for differing client needs. The nCS1 is also rising to prominence in the testing of exosomes, which are an active area of research for the treatment of cancer and other illnesses.
Key Features of the nCS1 include:
- – High resolution size and concentration measurements of particles from 50 nm to 10 μm in diameter
- – Concentration range: approx. 105 to 1012 particles/mL
- – Disposable microfluidic cartridges that avoid cross-contamination
- – Max particle detection rate: approx. 10,000 particles/second
- – Small sample volume required: only 3 μL
- – Nanoparticles of any material type (transparent & opaque, conducting & insulating)