PTL Volunteers in the Fight Against Respiratory Problems in Developing Nations
In September of 2011, PTL was pleased to host a group of researchers from Marquette University for a day of particle size measurements unlike any of our normal testing projects. PTL Fine Particle Analyst, Christopher Zmudka and VP of Analytical Services Bill Kopesky first learned to operate a nebulizer that does not require electricity, The Human Powered Nebulizer or (HPN). They then tested metered doses from the HPN for particle size distribution and compared the results to the droplet size produced from a conventional, electric nebulizer. The results were very promising and will allow the project to advance towards the ultimate goal of FDA approval and release.
PTL Fine Particle Analyst Jorie Kassel publishes article in GXP [Summer 2011] Issue
The Journal of GXP Compliance - [Summer 2011] issue features an article by PTL's Analyst, Jorie Kassel. Entitled Particle Dispersion for Size Analysis, this article addresses the importance in understanding while particle size analysis can provide great insight in the pharmaceutical industry, it can be nearly meaningless if obtained improperly. To learn more about the Journal of GXP Compliance and this article, visit www.gxpandjvt.com.
Particle Dispersion for Size Analysis
Jorie Kassel, Fine Particle Analyst II
ABSTRACT
Particle size analysis is a vital analytical tool in the pharmaceutical industry. The results can be
used to meet safety and quality specifications and provide information for product development
and manufacturing. While particle size analysis can provide great insight, it can be nearly
meaningless if it is obtained improperly. Errors observed in the generation of particle size data
occur due to the selection of a technique inappropriate to the material type or through the use
of poor sampling and dispersion techniques (i.e., sample preparation). In many cases, the end
application in which the particle size will be used is not properly considered, thus the amount of
dispersion needed is inadequate or overcompensated.
PTL now has the capability to allow for temperatures down to -150°C for Differential Scanning Calorimetry. PTL recently acquired Netzsch's liquid nitrogen cooling system, which extends the testing range from 600°C down to -150°C. PTL is excited about this increased ability to better serve our clients. Per Bill Kopesky, VP of Analytical Services, "We were seeing an increase in our clients request for freezing point suppression or much lower temperature ranges than before. Now we can easily satisfy these requests."